MonoTouch.Info - Entries tagged with Profiling
MonoTouch Article - Profiling Your MonoTouch Application
Beginning with MonoTouch 1.5 / 2.0 the MonoTouch team have introduced initial support for integrating with Apple Shark and Apple Instruments.   The profiling support is limited to the device but it is a great start! This page is on their site and provides more information about the profiling features.